The GET ON research project has been developed in collaboration with the “Towards 90-90-90” research consortium.
The research consortium fosters operational and clinical research aiming at achieving the UNAIDS 90-90-90 targets and generating evidence on innovative approaches for Lesotho and similar settings. The five institutions that are part of this consortium are the following:
- District Health Management Team of Butha-Buthe, Lesotho
- Ministry of Health of Lesotho
- Swiss Tropical and Public Health Institute, Basel, Switzerland
- SolidarMed, Swiss Organization for Health in Africa, Lesotho
- Molecular Virology, Department of Biomedicine, University of Basel, Switzerland
Publications from the research consortium (latest on top):
Glass TR, Motaboli L, Nsakala B, et al. The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho. PLOS ONE 2019; 14: e0220337.
Amstutz A, Lejone TI, Khesa L, et al. VIBRA trial – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho. Trials 2019; 20: 522.
Amstutz A, Lejone TI, Khesa L, et al. The HOSENG trial – Effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on testing coverage: protocol of a cluster-randomized clinical trial in rural Lesotho. Trials 2019; 20: 496.
Nadine Bachmann, Amrei von Braun, Niklaus D Labhardt, et al., the Swiss HIV Cohort Study; Importance of routine viral load monitoring: higher levels of resistance at ART failure in Uganda and Lesotho compared with Switzerland, Journal of Antimicrobial Chemotherapy, Volume 74, Issue 2, 1 February 2019, Pages 468–472
Labhardt ND, Ringera I, Lejone TI, Klimkait T, Muhairwe J, Amstutz A, and Glass TR. Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial. JAMA. United States; 2018
Labhardt ND, Ringera I, Lejone TI, Klimkait T, Muhairwe J, Amstutz A, and Glass TR. “SAME-DAY ART INITIATION AFTER HOME-BASED HIV TESTING: A RANDOMIZED CONTROLLED TRIAL.” Accepted as oral presentation at CROI March 4-7, 2018. 2018;Abstract Nb: 2357.
Amstutz A, Nsakala BL, Vanobberghen F, et al. SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa. BMC Infectious Diseases. (2018) 18:7.
Lejone TI, Ringera I, Cheleboi M, et al. The treatment cascade in children with unsuppressed viral load – a reality check in rural Lesotho, Southern Africa. J Acquir Immune Defic Syndr. November 2017. doi:10.1097/QAI.0000000000001597
Labhardt ND, Ringera I, Lejone TI, et al. When patients fail UNAIDS’ last 90 – the “failure cascade” beyond 90-90-90 in rural Lesotho, Southern Africa: a prospective cohort study. J Int AIDS Soc. Vol 20 No 1 2017. 2017.
Labhardt ND, Ringera I, Lejone TI, Muhairwe J, Fritz C, Klimkait T, Glass TR. “The first 90”: how close can we get with home-based HIV testing? First results from recruitment for the CASCADE trial in rural Lesotho. In: Abstracts of the HIV Glasgow Supplement, Journal of the International AIDS Society 2016. Glasgow UK; 2016. http://jiasociety.org/index.php/jias/issue/view/1485.
Labhardt ND, Ringera I, Lejone TI, et al. Same day ART initiation versus clinic-based pre-ART assessment and counselling for individuals newly tested HIV-positive during community-based HIV testing in rural Lesotho – a randomized controlled trial (CASCADE trial). BMC Public Health. 2016;16(1):1-8. doi:10.1186/s12889-016-2972-6
Cerutti B, Broers B, Masetsibi M, et al. Alcohol use and depression: link with adherence and viral suppression in adult patients on antiretroviral therapy in rural Lesotho, Southern Africa: a cross-sectional study. BMC Public Health. 2016;16:947. doi:10.1186/s12889-016-3209-4
Cerutti B, Bader J, Ehmer J, Pfeiffer K, Klimkait T, Labhardt ND. Performance of Risk Charts to Guide Targeted HIV Viral Load Monitoring of ART: Applying the Method on the Data From a Multicenter Study in Rural Lesotho. JAIDS J Acquir Immune Defic Syndr. 2016;72(1).
Puga D, Cerutti B, Molisana C, et al. Still Far From 90-90-90: Virologic Outcomes of Children on Antiretroviral Therapy in Nurse-led Clinics in Rural Lesotho. Pediatr Infect Dis J. 2016;35(1):78-80. doi:10.1097/INF.0000000000000929
Labhardt ND, Bader J, Lejone TI, et al. Should viral load thresholds be lowered?: Revisiting the WHO definition for virologic failure in patients on antiretroviral therapy in resource-limited settings. Zhong. P, ed. Medicine (Baltimore). 2016;95(28):e3985. doi:10.1097/MD.0000000000003985
Labhardt ND, Bader J, Lejone TI, et al. Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings? Trop Med Int Health. 2015;20(7):914-918. doi:10.1111/tmi.12509
Labhardt ND, Motlomelo M, Cerutti B, Pfeiffer K, Kamele M, Hobbins MA, Ehmer J. Home-Based Versus Mobile Clinic HIV Testing and Counseling in Rural Lesotho: A Cluster-Randomized Trial. PLoS Med. 2014;11:e1001768.
Labhardt ND, Bader J, Ramoeletsi M, et al. Clinical and socio-demographic predictors for virologic failure in rural Southern Africa: preliminary findings from CART-1. J Int AIDS Soc. 2014;17(4Suppl 3):19666. doi:10.7448/IAS.17.4.19666
Labhardt ND, Lejone T, Setoko M ’liso, et al. A Clinical Prediction Score in Addition to WHO Criteria for Anti-Retroviral Treatment Failure in Resource-Limited Settings – Experience from Lesotho. PLoS ONE. 2012;7(10):e47937. doi:10.1371/journal.pone.0047937
GET ON research project 