The Research Consortium

 

The GET ON research project has been developed in collaboration with the “Towards 90-90-90” research consortium.

The research consortium fosters operational and clinical research aiming at achieving the UNAIDS 90-90-90 targets and generating evidence on innovative approaches for Lesotho and similar settings. The five institutions that are part of this consortium are the following:

  1. District Health Management Team of Butha-Buthe, Lesotho
  2. Ministry of Health of Lesotho
  3. Swiss Tropical and Public Health Institute, Basel, Switzerland
  4. SolidarMed, Swiss Organization for Health in Africa, Lesotho
  5. Molecular Virology, Department of Biomedicine, University of Basel, Switzerland

 

 

Publications from the research consortium (latest on top):

Glass TR, Motaboli L, Nsakala B, et al. The viral load monitoring cascade in a resource-limited setting: A prospective multicentre cohort study after introduction of routine viral load monitoring in rural Lesotho. PLOS ONE 2019; 14: e0220337.

Amstutz A, Lejone TI, Khesa L, et al. VIBRA trial – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho. Trials 2019; 20: 522.

Amstutz A, Lejone TI, Khesa L, et al. The HOSENG trial – Effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on testing coverage: protocol of a cluster-randomized clinical trial in rural Lesotho. Trials 2019; 20: 496.

Nadine Bachmann, Amrei von Braun, Niklaus D Labhardt, et al., the Swiss HIV Cohort Study; Importance of routine viral load monitoring: higher levels of resistance at ART failure in Uganda and Lesotho compared with Switzerland, Journal of Antimicrobial Chemotherapy, Volume 74, Issue 2, 1 February 2019, Pages 468–472

Labhardt ND, Ringera I, Lejone TI, Klimkait T, Muhairwe J, Amstutz A, and Glass TR. Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial. JAMA. United States; 2018

Labhardt ND, Ringera I, Lejone TI, Klimkait T, Muhairwe J, Amstutz A, and Glass TR. “SAME-DAY ART INITIATION AFTER HOME-BASED HIV TESTING: A RANDOMIZED CONTROLLED TRIAL.” Accepted as oral presentation at CROI March 4-7, 2018. 2018;Abstract Nb: 2357.

Amstutz A, Nsakala BL, Vanobberghen F, et al. SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa. BMC Infectious Diseases. (2018) 18:7.

Lejone TI, Ringera I, Cheleboi M, et al. The treatment cascade in children with unsuppressed viral load – a reality check in rural Lesotho, Southern Africa. J Acquir Immune Defic Syndr. November 2017. doi:10.1097/QAI.0000000000001597

Labhardt ND, Ringera I, Lejone TI, et al. When patients fail UNAIDS’ last 90 – the “failure cascade” beyond 90-90-90 in rural Lesotho, Southern Africa: a prospective cohort study. J Int AIDS Soc. Vol 20 No 1 2017. 2017.

Labhardt ND, Ringera I, Lejone TI, Muhairwe J, Fritz C, Klimkait T, Glass TR. “The first 90”: how close can we get with home-based HIV testing? First results from recruitment for the CASCADE trial in rural Lesotho. In: Abstracts of the HIV Glasgow Supplement, Journal of the International AIDS Society 2016. Glasgow UK; 2016. http://jiasociety.org/index.php/jias/issue/view/1485.

Labhardt ND, Ringera I, Lejone TI, et al. Same day ART initiation versus clinic-based pre-ART assessment and counselling for individuals newly tested HIV-positive during community-based HIV testing in rural Lesotho – a randomized controlled trial (CASCADE trial). BMC Public Health. 2016;16(1):1-8. doi:10.1186/s12889-016-2972-6

Cerutti B, Broers B, Masetsibi M, et al. Alcohol use and depression: link with adherence and viral suppression in adult patients on antiretroviral therapy in rural Lesotho, Southern Africa: a cross-sectional study. BMC Public Health. 2016;16:947. doi:10.1186/s12889-016-3209-4

Cerutti B, Bader J, Ehmer J, Pfeiffer K, Klimkait T, Labhardt ND. Performance of Risk Charts to Guide Targeted HIV Viral Load Monitoring of ART: Applying the Method on the Data From a Multicenter Study in Rural Lesotho. JAIDS J Acquir Immune Defic Syndr. 2016;72(1).

Puga D, Cerutti B, Molisana C, et al. Still Far From 90-90-90: Virologic Outcomes of Children on Antiretroviral Therapy in Nurse-led Clinics in Rural Lesotho. Pediatr Infect Dis J. 2016;35(1):78-80. doi:10.1097/INF.0000000000000929

Labhardt ND, Bader J, Lejone TI, et al. Should viral load thresholds be lowered?: Revisiting the WHO definition for virologic failure in patients on antiretroviral therapy in resource-limited settings. Zhong. P, ed. Medicine (Baltimore). 2016;95(28):e3985. doi:10.1097/MD.0000000000003985

Labhardt ND, Bader J, Lejone TI, et al. Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings? Trop Med Int Health. 2015;20(7):914-918. doi:10.1111/tmi.12509

Labhardt ND, Motlomelo M, Cerutti B, Pfeiffer K, Kamele M, Hobbins MA, Ehmer J. Home-Based Versus Mobile Clinic HIV Testing and Counseling in Rural Lesotho: A Cluster-Randomized Trial. PLoS Med. 2014;11:e1001768.

Labhardt ND, Bader J, Ramoeletsi M, et al. Clinical and socio-demographic predictors for virologic failure in rural Southern Africa: preliminary findings from CART-1. J Int AIDS Soc. 2014;17(4Suppl 3):19666. doi:10.7448/IAS.17.4.19666

Labhardt ND, Lejone T, Setoko M ’liso, et al. A Clinical Prediction Score in Addition to WHO Criteria for Anti-Retroviral Treatment Failure in Resource-Limited Settings – Experience from Lesotho. PLoS ONE. 2012;7(10):e47937. doi:10.1371/journal.pone.0047937